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Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse reactions (e.g. stroke, transient ischemic attack, including fatalities). Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring. Tardive Dyskinesia: Discontinue if clinically appropriate. Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain. Hyperglycemia/Diabetes Mellitus: Monitor glucose regularly in patients with and at risk for diabetes. Dyslipidemia: Undesirable alterations in lipid levels have been observed in patients treated with atypical antipsychotics. Weight Gain: Weight gain has been observed with atypical antipsychotic use. Monitor weight. Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation. Falls: Antipsychotics may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls. Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope. Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including ABILIFY. Patients with a history of a clinically significant low white blood cell count (WBC or a drug-induced leukopenia/neutropenia should have their complete blood count (CBC monitored frequently during the first few months of therapy and discontinuation of ABILIFY should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors. Seizures/Convulsions: Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold. Potential for Cognitive and Motor Impairment: Use caution when operating machinery. Suicide: The possibility of a suicide attempt is inherent in schizophrenia and bipolar disorder. Closely supervise high-risk patients.
The tablet and embedded sensor is called Abilify MyCite. Abilify, made by Japan-based Otsuka Pharmaceutical, is the brand-name version of aripiprazole, an antipsychotic drug used for treating schizophrenia, bipolar disorder and as an add-on treatment for depression in adults.
Abilify, a drug commonly prescribed to treat mental health conditions, has been linked to causing serious side effects. Studies have shown an increased risk of compulsive behaviors eating disorders, gambling addictions and other addictions in patients taking Abilify. This research has led to an alarming number of lawsuits against Abilify manufacturers.
The Department of Justice filed a lawsuit against Bristol-Myers Squibb alleging the drug company promoted Abilify for off-label use, in violation of federal law. The lawsuit alleges the drug was promoted for use in the treatment of dementia-related psychosis and for pediatric use. The lawsuit was settled for $515 million.
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abilify should be used with caution in patients with diabetes or other disorders of glucose regulation and patients should be monitored for worsening of glucose control.