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In Phase I and II controlled trialsthe following adverse events were reported significantly more frequently by those randomized to the arms containing CRIXIVAN than by those randomized to nucleoside analoguesrashupper respiratory infectiondry skinpharyngitistaste perversion.

Clinically significant adverse reactionspotentially leading to severelife-threateningor fatal events from greater exposures of concomitant medicationsClinically significant adverse reactions from greater exposures of CRIXIVANLoss of therapeutic effect of CRIXIVAN and possible development of resistance.

The precise causes of the HIV lipodystrophy syndrome are not clear and are difficult to understand because in some people with HIV there may be one or more aspects of the syndrome taking placeFor instancesome people may experience fat wastingothers fat gainand others may experience both fat gain and wastingWhat is becoming increasingly clear is that unfavourable changes in the lab readings of glucosecholesteroland triglycerides over a period of several years increase the risk of diabetes and cardiovascular diseaseSo farhoweverthe many benefits of ART are much greater than the increased risk of cardiovascular disease or other side effects.

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