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Isoniazid has rarely caused very serious (possibly fatal) liver disease. The risk of liver disease is increased in people who are 35 years and older.who use alcohol or illegal injection drugs.or who currently have long-term liver problems. Tell your doctor right away if you develop symptoms of liver disease.including persistent nausea/vomiting.severe stomach/abdominal pain.unusual weakness/tiredness.dark urine.yellowing eyes/skin.

There seems to be an increased cheap isoniazid and rifampin of fatal hepatitis among women.particularly African-American and Hispanic women. The risk also may be increased during postpartum or immediately after pregnancy. Because of the risk of hepatitis.patients taking isoniazid should have their blood liver tests monitored monthly and should notify their physicians immediately if symptoms or signs of hepatitis arise. These symptoms and signs include.

sudden weakness or ill feeling.or fever for 3 days or longer. pain in your upper stomach (may spread to your back) isoniazid and rifampin of appetite. dark urine.clay-colored stools.jaundice (yellowing of the skin or eyes). vision changes.pain behind your eyes. confusion.memory problems.unusual thoughts or behavior. a seizure (convulsions). or pale skin.easy bruising or bleeding (nosebleeds.bleeding gums).

Women who are African American.Hispanic.or who’ve just had a baby may be at an increased risk for developing liver problems while taking isoniazid.

Your doctor should order liver function tests while you are taking this medication. Keep all medical and laboratory appointments.

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likewise, acetaminophen interacts with drugs that increase liver enzymes, such as carbamazepine, isoniazid and rifampin, all of which reduce acetaminophen s effect.

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