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The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies
The protonix over the counter equivalent. recommended dosage is one drop in the affected eye(sonce daily in the eveningIf one dose is missedtreatment should continue with the next dose as normal.
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most importantly, the introduction of generic latanoprost, the most widely prescribed glaucoma medication, has led to variability in both efficacy and tolerability in some patients who were previously controlled on the xalatan branded preparation.