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Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy prevention of nausea and vomiting associated with radiotherapy prevention of postoperative nausea and/or vomiting.

Zofran is linked to possible side effectssome of which are seriousincluding serotonin syndrome and QT interval prolongation.

Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observeddata from 2 small trials indicate that when used togetherZOFRAN may increase patient-controlled administration of tramadolMonitor patients to ensure adequate pain control when ondansetron is administered with tramadol.

Ondansetron orally disintegrating tablets may contain phenylalanineTell your doctor if you have phenylketonuriaPKU

The FDA had previously noted that ondansetron could increase the risk of developing QT interval prolongationThe agency also pointed to articles published in the medical literature that describe QT interval prolongation with ondansetron.

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