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Administration of live or liveattenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroidsKilled or inactivated vaccines may be administeredHoweverthe response to such vaccines cannot be predictedImmunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapye.gfor Addison’s disease.

Glucocorticoidsnaturally occurring and syntheticare adrenocortical steroids that are readily absorbed from the gastrointestinal tractGlucocorticoids cause varied metabolic effectsIn additionthey modify the body’s immune responses to diverse stimuliNaturally occurring glucocorticoidshydrocortisone and cortisonewhich also have sodium-retaining propertiesare used as replacement therapy in adrenocortical deficiency statesTheir synthetic analogs including dexamethasone are primarily used for their anti-inflammatory effects in disorders of many organ systems.

Corticosteroids do occur naturally in the body and help to maintain health and well-beingSynthetic steroids such as dexamethasone work by mimicking some of their actions to treat disease.

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Ephedrine may enhance the metabolic clearance of corticosteroidsresulting in decreased blood levels and lessened physiologic activitythus requiring an increase in corticosteroid dosage.

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remember that when you are placed on decadron, your body senses the glucocorticosteroid and tells itself that it no longer needs to make its own cortisol.

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