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Patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or attenuated vaccines due to inhibition of antibody response. Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible (see WARNINGS. Infections.Vaccinations ).

If for any reason you take your SOLU-MEDROL home.always ensure that it is stored in a place where children cannot reach it.

If you miss a dose of this medicine.take it as soon as possible. However.if it is almost time for your next dose.skip the missed dose and go back to your regular dosing schedule. Do not double doses.

It is very important to tell your doctor if you notice any side effects during a course of treatment with SOLU-MEDROL.

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the action of depo-medrol injected intrasynovially appears to be well localized since significant metabolic effects characteristic of systemic administration of adrenal steroids have not been observed.

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