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DUse in LIFE-THREATENING emergencies when no safer drug availablePositive evidence of human fetal risk.

The CHMP also harmonised other sections of the SmPC including sections 4.5interaction with other medicinal products and other forms of interactionand 5.1pharmacodynamic properties

Tell your doctor if your condition does not improve or if it worsensfor exampleyour blood pressure readings remain high or increasechest pain continues or worsens

As with other calcium channel blockershemodynamic measurements of cardiac function at rest and during exerciseor pacingin patients with normal ventricular function treated with Norvasc have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volumeIn hemodynamic studiesNorvasc has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and maneven when co-administered with beta-blockers to manSimilar findingshoweverhave been observed in normal or well-compensated patients with heart failure with agents possessing significant negative inotropic effects.

As with other calcium channel blockershemodynamic measurements of cardiac function at rest and during exerciseor pacingin patients with normal ventricular function treated with Norvasc have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volumeIn hemodynamic studiesNorvasc has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and maneven when co-administered with beta-blockers to manSimilar findingshoweverhave been observed in normal or well-compensated patients with heart failure with agents possessing significant negative inotropic effects.

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