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The most common signs and symptoms observed are those caused by electrolyte depletionhypokalemiahypochloremiahyponatremiaand dehydration resulting from excessive diuresisIf digitalis has also been administeredhypokalemia may accentuate cardiac arrhythmias.

CommentsSome patients respond to intermittent therapyi.eadministration on alternate days or on 3 to 5 days each weekExcessive response and undesirable electrolyte imbalance are less likely to occur with intermittent dosing.

To reduce the risk of dizziness and lightheadednessget up slowly when rising from a sitting or lying position.

The most common signs and symptoms observed are those caused by electrolyte depletionhypokalemiahypochloremiahyponatremiaand dehydration resulting from excessive diuresisIf digitalis has also been administeredhypokalemia may accentuate cardiac arrhythmias.

Whenever adverse reactions are moderate or severethiazide dosage should be reduced or therapy withdrawn.

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valsartan; hydrochlorothiazide should be used with caution in patients with a history of pancreatitis.

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