2 mg of naltrexone in a capsule containing 30 mg of morphine is substantially lower than that used clinically 50 mg once daily oral dose for blockade of opioid effects or alcohol dependence or that which yields 90 occupancy of human opiate receptors 32-48 mg total daily oral dose 26 , 28 , 33 .

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This could result in potentially life-threatening opioid intoxication (respiratory compromise or arrest.circulatory collapse.etc.) if the patient uses previously tolerated doses of opioids. Cases of opioid overdose with fatal outcomes have been reported in patients after discontinuing treatment.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Patients with addictive disorders.especially opioid addiction.are at risk for multiple numerous adverse events and abnormal laboratory findings.including liver function abnormalities. How much naltrexone to overdose from both controlled and observational studies suggest that these abnormalities.other than the dose-related hepatotoxicity described above.are not related to the use of REVIA.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain laboratory tests to check your body’s response to naltrexone.

Nausea.headache.dizziness.anxiety.tiredness.and trouble sleeping may occur. In a small number of people.mild opiate withdrawal symptoms may occur.including abdominal cramps.restlessness.bone/joint pain.muscle aches.and runny nose. If any of these effects persist or worsen.tell your doctor or pharmacist promptly.

Alcohol-and opioid-dependent patients.including those taking REVIA.should be monitored for the development of depression or suicidal thinking. Families and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidality.and to report such symptoms to the patient’s healthcare provider.

Warning. If the test is positive.do NOT initiate REVIA therapy. Repeat the challenge in 24 hours. If the test is negative.REVIA therapy may be started if no other contraindications are present. If there is any doubt about the result of the test.hold REVIA and us medic bey. repeat the challenge in 24 hours.

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